When you’re tight with Chelsea Handler, at least you know she’s going to have your back should things get a little dicey. You may or may not be aware of the fact that Handler and Jennifer Anniston are pretty close friends, which means that the comedienne isn’t exactly the biggest fan of actress Angelina Jolie. After all, how could you support the woman who stole your best friend’s husband? Now you see where I’m going with this.

In a recent interview with More magazine, Handler was asked for an example of someone who isn’t a “girl’s girl”. You know, someone who isn’t going to stab you in the back and spirit away your beau for her own personal use. Not surprisingly, Handler’s first choice was Angelina Jolie.

Specifically, here’s what she had to say about the actress:

Probably Angelina Jolie. She doesn’t strike me as someone I would have a close friendship with. You just know as a woman, when you see another woman, if that’s a woman you can trust.

Ouch. As harsh as that statement may seem, this isn’t the first time that Handler has lashed out at the star of such films as “The Changeling”, “Wanted”, and “Mr. and Mrs. Smith”. In fact, it was Jolie’s controversial relationship with Pitt that sparked Handler’s previous comments.

During her stand-up shows back in 2010, Handler had this to say about the actress:

She’s a homewrecker, she is. She gives interviews, ‘I don’t have a lot of female friends.’ Because you’re a f—ing c—. You’re a f—ing b—-!

Is Handler just protecting a friend, or has she taken this war of dirty words too far? Here’s what Twitter fans had to say on this whole sordid Handler/Jolie affair.